rec. Human Insulin-Like Growth Factor I (rHulGF-I) 20 µg

rec. Human Insulin-Like Growth Factor-I aus E.Coli ist ein nichtglycosyliertes Polypeptid von 70 Aminosäuren mit einer Molmasse von 7655 Dalton. Synonyme: Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF.

The somatomedins, or insulin-like growth factors (IGFs), comprise a family of peptides that play important roles in mammalian growth and development. IGF1 mediates many of the growth-promoting effects of growth hormone (GH; MIM 139250). Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed 'sulfation factor,' which later became known as 'somatomedin' (Daughaday et al., 1972). Three main somatomedins have been characterized: somatomedin C (IGF1), somatomedin A (IGF2; MIM 147470), and somatomedin B (MIM 193190) (Rotwein, 1986; Rosenfeld, 2003). The ED50, calculated by the dose-dependant proliferation of murine BALBC 3T3 cells (measured by 3H-thymidine uptake) is 1.0ng/mL, corresponding to a specific activity of 1 x 10(6) U/mg. For most in-vitro applications, IGF-I exerts its biological activity in the concentration range of 0.2-20ng/mL.